New Research Traces Evolutionary Path of Multidrug-Resistant Streptococcus
In a landmark paper published this week in Science, scientists from Rockefeller University and the Sanger Institute have used full genome sequencing to identify the precise steps in the molecular evolution of Streptococcus pneumoniae. Their research shows the changes the genome of this bacterium has undergone in time and during its massive geographic spread over the globe.
The researchers, led by the Sanger Institute's Stephen D. Bentley, used high resolution genome sequencing on clinical isolates of S. pneumoniae provided by a number of collaborating laboratories, including the Laboratory of Microbiology and Infectious Diseases at Rockefeller University, headed by Alexander Tomasz. With data available for the date, geographic site and infection site of these isolates, Bentley and colleagues were able to produce a roadmap for the evolution of a major multidrug resistant clones of pneumococci known as the PMEN clone 1, sequence type 81.
"The phenomenon of genetic transformation, which led Oswald Avery and his Rockefeller colleagues in 1944 to identify DNA as the genetic material, is the very process that Streptococcus pneumoniae uses during evolution in its real in vivo environment," says Tomasz.
For more info visit http://www.eurekalert.org/pub_releases/2011-01/ru-nrt012811.php
In a landmark paper published this week in Science, scientists from Rockefeller University and the Sanger Institute have used full genome sequencing to identify the precise steps in the molecular evolution of Streptococcus pneumoniae. Their research shows the changes the genome of this bacterium has undergone in time and during its massive geographic spread over the globe.
The researchers, led by the Sanger Institute's Stephen D. Bentley, used high resolution genome sequencing on clinical isolates of S. pneumoniae provided by a number of collaborating laboratories, including the Laboratory of Microbiology and Infectious Diseases at Rockefeller University, headed by Alexander Tomasz. With data available for the date, geographic site and infection site of these isolates, Bentley and colleagues were able to produce a roadmap for the evolution of a major multidrug resistant clones of pneumococci known as the PMEN clone 1, sequence type 81.
"The phenomenon of genetic transformation, which led Oswald Avery and his Rockefeller colleagues in 1944 to identify DNA as the genetic material, is the very process that Streptococcus pneumoniae uses during evolution in its real in vivo environment," says Tomasz.
For more info visit http://www.eurekalert.org/pub_releases/2011-01/ru-nrt012811.php
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